The African Bioinformatics Institute (ABI) is in the process of being established with the goal of advancing life science research across the African continent. By providing essential resources, expertise, and infrastructure in bioinformatics, the ABI aims to tackle key challenges in African health and life sciences, contributing to the achievement of the Sustainable Development Goals. Through innovative bioinformatics research, capacity building, and the creation of cutting-edge solutions, the ABI offers a unique opportunity to positively impact the health and well-being of Africa’s people, flora and fauna.